General Information
Arousal Cream, which also goes by the name of Scream Cream, is a topical cream that, when applied to the clitoris or external genitalia, can increase blood flow to the applied area and has been reported to improve sensitivity and rates of orgasm. Com-
pounded from a mixture of prescription products, Arousal Cream is designed to act locally without substantial absorption into
the blood stream. This transdermal (absorbed through the skin) cream is comprised of six different medications and products
which include: aminophylline, ergoloid mesylate, L-arginine, pentoxifylline, sildenafil citrate, and testosterone. This synergistic
medication draws upon the properties of each ingredient (one bronchodilator, four vasodilators, and the potent sex steroid
hormone testosterone) that can provide female libido (sex drive) and sexual stimulation enhancement.
Mechanism of Action
Arousal Cream’s four vasodilators contribute by relaxing the vascular smooth muscles, which consequently dilates peripheral
blood vessels (arteries and especially veins). Dilatation (widening) of the blood vessels promotes peripheral pooling of blood
and decreases venous return to the heart, thereby reducing left ventricular end-diastolic pressure and pulmonary capillary
wedge pressure (preload). Such medications are primarily used to treat or prevent heart disease due to arterial plaque
buildup, blood clots, platelet clumping, and to increase blood flow through the coronary artery. These medications are also used to ease migraines, improve blood pressure to organs and tissues, lessen recovery time after surgery, increase immune-
boosting effects, and speed up tissue repair/wound healing. However, they contribute to the Arousal Cream complex by ex-
erting effects on the female genitalia. The same vasoactive mechanisms used by these agents to improve blood flow to the heart, lungs, and many other bodily tissues and functions, is believed to also increase vaginal blood flow during stimulation,
thereby effectively aiding in the treatment of sexual dysfunctions.
Precautions
If you have contraindications with intercourse, you should consult your healthcare provider before using the medication and
engaging in intercourse. You should not use this cream if you are allergic to any of the ingredients, have a history of genital
herpes (*L-Arginine may facilitate replication of the herpes virus. An alternative formulation without L-Arginine is available.),
chronic vaginal infections, or serious medical conditions such as heart disease or autoimmune disorder. Additionally, despite
acting almost exclusively locally, the contraindications for each of Arousal Cream’s compounds may apply. Provide your physi-
cian with information on Arousal Cream, as well as a list of your medical conditions before asking for a prescription.
Pregnancy
DO NOT USE AROUSAL CREAM while pregnant or trying to become pregnant: one of Arousal Cream’s ingredients, Testos-
terone, is an FDA pregnancy risk category X (adverse fetal effects are expected).
Breast Feeding
As a testosterone-containing product, Arousal Cream is contraindicated in women who are breast-feeding.
Interactions Arousal
Arousal Cream acts synergistically via six distinct pharmacologically active compounds and each has its own list of compounds
it interacts with. Interactions resulting from the combination of these compounds have not been studied and may include
more than the sum of all compounds. Give your health care provider a list of all the medicines, herbs, non-prescription drugs,
or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with
your medicine.
Side Effects
Arousal Cream promotes blood flow to the applied area to improve sensitivity and rates of orgasm: it does not produce an or-
gasm. If not completely absorbed, it may cause irritation with your partner. Arousal Cream is formulated to act locally so side effects are minimal, but may include skin irritation, headache, dizziness, and restlessness. However, possible side effects in-
clude but are not limited to those of each of Arousal Cream’s components. The side effects of these compounds in combina-
tion have not been studied.
Call your Primary Health Care Physician immediately if you are experiencing any signs of an allergic reaction: skin rash, itching
or hives, swelling of the face, lips, or tongue, blue tint to skin, chest tightness, pain, difficulty breathing, wheezing, dizziness,
How is this medication best taken?
Apply 1/4 – 1/2 mL of cream onto clitoris and/or external genital 15-30 minutes prior to sex. Arousal Cream should be massaged gently into the area until it is completely absorbed. Duration of effect is 30 minutes to 2 hours and reapplication may occur as needed.
Make sure to talk to your Primary Health Care Physician or pharmacist about how frequently you should be using Arousal
Cream and how much you should apply.
Storage
Store this medication at 68°F to 77°F (20°C to 25°C) and away from heat, moisture and light. Keep all medicine out of the reach
of children. Throw away any unused medicine after the beyond use date. Do not flush unused medications or pour down a sink
or drain.
